With his blond ponytail and tiny shades, comic book artist Sketch Turner is as hip as they come. But all the hipness in the world will not help him when his own creations turn against him. Mortus, the main villain in his comic book comes to life after a bizarre thunderstorm. Unable to harm Sketch in the real world, Mortus blasts the artist into his own comic book, where he must fight off an army of mutant warriors. When he lands in his post-apocalyptic comic world, Sketch befriends Alissa Cyan, who leads a resistance against the mutants and gives Sketch mission briefings as he fights. Since the action takes place in a comic book, the banter appears in word bubbles, and Sketch hops across comic panels to enter the next area.
- The score for Comix Zone was composed by Howard Drossin. Drossin had previously written the music to Sonic The Hedgehog 3 and Sonic & Knuckles